Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner | Zendy

Ping Song | Zendy; Yong Wu | Zendy; Jian Xu | Zendy; Zhonglin Xie | Zendy; Yunzhou Dong | Zendy; Miao Zhang | Zendy; Ming-Hui Zou | Zendy

Open Access

Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner

Author(s) -

Ping Song,

Yong Wu,

Jian Xu,

Zhonglin Xie,

Yunzhou Dong,

Miao Zhang,

Ming-Hui Zou

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.716498

Subject(s) - pten , tensin , protein kinase b , phosphorylation , small interfering rna , phosphatase , pi3k/akt/mtor pathway , cancer research , biology , microbiology and biotechnology , signal transduction , biochemistry , transfection , gene

Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood.

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