Platelet-Derived Stromal Cell–Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34 + Cells to Endothelial Progenitor Cells | Zendy

Konstantinos Stellos | Zendy; Harald F. Langer | Zendy; Karin Daub | Zendy; Tanja Schoenberger | Zendy; Alexandra Gauß | Zendy; Tobias Geisler | Zendy; Boris Bigalke | Zendy; Iris Mueller | Zendy; Michael Schumm | Zendy; Iris Schaefer | Zendy; Peter Seizer | Zendy; Bjoern F. Kraemer | Zendy; Dorothea SiegelAxel | Zendy; Andreas E. May | Zendy; Stephan Lindemann | Zendy; Meinrad Gawaz | Zendy

Open Access

Platelet-Derived Stromal Cell–Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34 ⁺ Cells to Endothelial Progenitor Cells

Author(s) -

Konstantinos Stellos,

Harald F. Langer,

Karin Daub,

Tanja Schoenberger,

Alexandra Gauß,

Tobias Geisler,

Boris Bigalke,

Iris Mueller,

Michael Schumm,

Iris Schaefer,

Peter Seizer,

Bjoern F. Kraemer,

Dorothea SiegelAxel,

Andreas E. May,

Stephan Lindemann,

Meinrad Gawaz

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.714691

Subject(s) - progenitor cell , microbiology and biotechnology , homing (biology) , endothelial stem cell , cd34 , stem cell , stromal cell , vasculogenesis , immunology , biology , cancer research , in vitro , biochemistry , ecology

Peripheral homing of progenitor cells in areas of diseased organs is critical for tissue regeneration. The chemokine stromal cell-derived factor-1 (SDF-1) regulates homing of CD34+ stem cells. We evaluated the role of platelet-derived SDF-1 in adhesion and differentiation of human CD34+ cells into endothelial progenitor cells.

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