Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction | Zendy

Dirk Westermann | Zendy; Jan Mersmann | Zendy; A. Melchior | Zendy; Till Freudenberger | Zendy; Christian Petrik | Zendy; Liliana Schaefer | Zendy; Renate LüllmannRauch | Zendy; Olga Lettau | Zendy; Christoph Jacoby | Zendy; Jürgen Schrader | Zendy; StefanMartin BrandHerrmann | Zendy; Marian F. Young | Zendy; HeinzPeter Schultheiß | Zendy; Bodo Levkau | Zendy; Hideo A. Baba | Zendy; T Unger | Zendy; Kai Zacharowski | Zendy; Carsten Tschöpe | Zendy; Jens W. Fischer | Zendy

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Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction

Author(s) -

Dirk Westermann,

Jan Mersmann,

A. Melchior,

Till Freudenberger,

Christian Petrik,

Liliana Schaefer,

Renate LüllmannRauch,

Olga Lettau,

Christoph Jacoby,

Jürgen Schrader,

StefanMartin BrandHerrmann,

Marian F. Young,

HeinzPeter Schultheiß,

Bodo Levkau,

Hideo A. Baba,

T Unger,

Kai Zacharowski,

Carsten Tschöpe,

Jens W. Fischer

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.714147

Subject(s) - biglycan , medicine , hemodynamics , cardiology , ventricular remodeling , myocardial infarction , diastole , blood pressure , anatomy , decorin , proteoglycan , cartilage

After myocardial infarction (MI), extensive remodeling of extracellular matrix contributes to scar formation and preservation of hemodynamic function. On the other hand, adverse and excessive extracellular matrix remodeling leads to fibrosis and impaired function. The present study investigates the role of the small leucine-rich proteoglycan biglycan during cardiac extracellular matrix remodeling and cardiac hemodynamics after MI.

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