Resynchronization of Separated Rat Cardiomyocyte Fields With Genetically Modified Human Ventricular Scar Fibroblasts | Zendy

Daniël A. Pijnappels | Zendy; John van Tuyn | Zendy; Antoine A.F. de Vries | Zendy; Robert W Grauss | Zendy; Arnoud van der Laarse | Zendy; Dirk L. Ypey | Zendy; Douwe E. Atsma | Zendy; Martin J. Schalij | Zendy

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Resynchronization of Separated Rat Cardiomyocyte Fields With Genetically Modified Human Ventricular Scar Fibroblasts

Author(s) -

Daniël A. Pijnappels,

John van Tuyn,

Antoine A.F. de Vries,

Robert W Grauss,

Arnoud van der Laarse,

Dirk L. Ypey,

Douwe E. Atsma,

Martin J. Schalij

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.712935

Subject(s) - medicine , intracellular , cardiac resynchronization therapy , heart failure , gene expression , connexin , stimulation , gap junction , microbiology and biotechnology , gene , biology , genetics , ejection fraction

Nonresponse to cardiac resynchronization therapy is associated with the presence of slow or nonconducting scar tissue. Genetic modification of scar tissue, aimed at improving conduction, may be a novel approach to achieve effective resynchronization. Therefore, the feasibility of resynchronization with genetically modified human ventricular scar fibroblasts was studied in a coculture model.

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