Nitrite Infusion in Humans and Nonhuman Primates | Zendy

Andrè Dejam | Zendy; Christian J. Hunter | Zendy; Carole K. Tremonti | Zendy; Ryszard Pluta | Zendy; Yuen Yi Hon | Zendy; George Grimes | Zendy; Kristine Partovi | Zendy; Mildred M. Pelletier | Zendy; Edward H. Oldfield | Zendy; Richard O. Can | Zendy; Alan N. Schechter | Zendy; Mark T. Gladwin | Zendy

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Nitrite Infusion in Humans and Nonhuman Primates

Author(s) -

Andrè Dejam,

Christian J. Hunter,

Carole K. Tremonti,

Ryszard Pluta,

Yuen Yi Hon,

George Grimes,

Kristine Partovi,

Mildred M. Pelletier,

Edward H. Oldfield,

Richard O. Can,

Alan N. Schechter,

Mark T. Gladwin

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.712133

Subject(s) - nitric oxide , nitrite , vasodilation , pharmacology , nitrate , medicine , xanthine oxidase , biochemistry , nitrite reductase , chemistry , enzyme , organic chemistry

The recent discovery that nitrite is an intrinsic vasodilator and signaling molecule at near-physiological concentrations has raised the possibility that nitrite contributes to hypoxic vasodilation and to the bioactivity of nitroglycerin and mediates the cardiovascular protective effects of nitrate in the Mediterranean diet. However, important questions of potency, kinetics, mechanism of action, and possible induction of tolerance remain unanswered.

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