Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo | Zendy

Wah-Seng Lim | Zendy; Jenelle M. Timmins | Zendy; Tracie A. Seimon | Zendy; Anthony J. Sadler | Zendy; Frank D. Kolodgie | Zendy; Renu Virmani | Zendy; Ira Tabas | Zendy

Open Access

Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo

Author(s) -

Wah-Seng Lim,

Jenelle M. Timmins,

Tracie A. Seimon,

Anthony J. Sadler,

Frank D. Kolodgie,

Renu Virmani,

Ira Tabas

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.711275

Subject(s) - endoplasmic reticulum , medicine , microbiology and biotechnology , in vivo , apoptosis , in vitro , stat protein , activator (genetics) , signal transduction , biology , stat3 , biochemistry , receptor

Macrophage apoptosis is a critical process in the formation of necrotic cores in vulnerable atherosclerotic plaques. In vitro and in vivo data suggest that macrophage apoptosis in advanced atheromata may be triggered by a combination of endoplasmic reticulum stress and engagement of the type A scavenger receptor, which together induce death through a rise in cytosolic calcium and activation of toll-like receptor-4.

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