Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 + T-Cell–Mediated Injury in the Heart | Zendy

Nir Grabie | Zendy; Israel Gotsman | Zendy; Rosa DaCosta | Zendy; Hong Pang | Zendy; George Stavrakis | Zendy; Manish J. Butte | Zendy; Mary E. Keir | Zendy; Gordon J. Freeman | Zendy; Arlene H. Sharpe | Zendy; Andrew H. Lichtman | Zendy

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Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 ⁺ T-Cell–Mediated Injury in the Heart

Author(s) -

Nir Grabie,

Israel Gotsman,

Rosa DaCosta,

Hong Pang,

George Stavrakis,

Manish J. Butte,

Mary E. Keir,

Gordon J. Freeman,

Arlene H. Sharpe,

Andrew H. Lichtman

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.709360

Subject(s) - cytotoxic t cell , medicine , myocarditis , immune system , inflammation , cd8 , immunology , t cell , pd l1 , bone marrow , blocking antibody , lymphocyte , antibody , biology , immunotherapy , biochemistry , in vitro

PD-L1 and PD-L2 are ligands for the inhibitory receptor programmed death-1 (PD-1), which is an important regulator of immune responses. PD-L1 is induced on cardiac endothelial cells under inflammatory conditions, but little is known about its role in regulating immune injury in the heart.

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