Matrix Metalloproteinase-14 Deficiency in Bone Marrow–Derived Cells Promotes Collagen Accumulation in Mouse Atherosclerotic Plaques | Zendy

F. Schneider | Zendy; Galina K. Sukhova | Zendy; Masanori Aikawa | Zendy; James P. Canner | Zendy; Norbert Gerdes | Zendy; Sai-Man Timothy Tang | Zendy; GuoPing Shi | Zendy; Suneel Apte | Zendy; Peter Libby | Zendy

Open Access

Matrix Metalloproteinase-14 Deficiency in Bone Marrow–Derived Cells Promotes Collagen Accumulation in Mouse Atherosclerotic Plaques

Author(s) -

F. Schneider,

Galina K. Sukhova,

Masanori Aikawa,

James P. Canner,

Norbert Gerdes,

Sai-Man Timothy Tang,

GuoPing Shi,

Suneel Apte,

Peter Libby

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.707448

Subject(s) - medicine , matrix metalloproteinase , bone marrow , pathology , matrix (chemical analysis) , bone matrix , anatomy , cartilage , materials science , composite material

Interstitial collagen plays a crucial structural role in arteries. Although in vitro results suggest collagenase activity for membrane-bound matrix metalloproteinase type 1 (MMP-14), in vivo evidence for such a function in atherosclerosis remains scant.

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