Control of In Vivo Contraction/Relaxation Kinetics by Myosin Binding Protein C | Zendy

Takahiro Nagayama | Zendy; Eiki Takimoto | Zendy; Sakthivel Sadayappan | Zendy; James O. Mudd | Zendy; Jonathan G. Seidman | Zendy; Jeffrey Robbins | Zendy; David A. Kass | Zendy

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Control of In Vivo Contraction/Relaxation Kinetics by Myosin Binding Protein C

Author(s) -

Takahiro Nagayama,

Eiki Takimoto,

Sakthivel Sadayappan,

James O. Mudd,

Jonathan G. Seidman,

Jeffrey Robbins,

David A. Kass

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.706523

Subject(s) - medicine , contraction (grammar) , myosin , kinetics , in vivo , biophysics , muscle contraction , microbiology and biotechnology , genetics , biology , physics , quantum mechanics

Cardiac myosin binding protein-C (cMyBP-C) is a thick-filament protein whose presence and phosphorylation by protein kinase A (PKA) regulates cross-bridge formation and kinetics in isolated myocardium. We tested the influence of cMyBP-C and its PKA-phosphorylation on contraction/relaxation kinetics in intact hearts and revealed its essential role in several classic properties of cardiac function.

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