Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization | Zendy

Khalid Chakir | Zendy; Samantapudi K. Daya | Zendy; Richard S. Tunin | Zendy; Robert Helm | Zendy; Melissa Byrne | Zendy; Veronica L. Dimaano | Zendy; Albert C. Lardo | Zendy; Theodore P. Abraham | Zendy; Gordon F. Tomaselli | Zendy; David A. Kass | Zendy

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Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization

Author(s) -

Khalid Chakir,

Samantapudi K. Daya,

Richard S. Tunin,

Robert Helm,

Melissa Byrne,

Veronica L. Dimaano,

Albert C. Lardo,

Theodore P. Abraham,

Gordon F. Tomaselli,

David A. Kass

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.706291

Subject(s) - medicine , cardiac resynchronization therapy , cardiology , apoptosis , kinase , heart failure , microbiology and biotechnology , ejection fraction , genetics , biology

Cardiac dyssynchrony in the failing heart worsens global function and efficiency and generates regional loading disparities that may exacerbate stress-response molecular signaling and worsen cell survival. We hypothesized that cardiac resynchronization (CRT) from biventricular stimulation reverses such molecular abnormalities at the regional and global levels.

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