Identification of Promoter Variants in Baboon Endothelial Lipase That Regulate High-Density Lipoprotein Cholesterol Levels | Zendy

Laura A. Cox | Zendy; Shifra Birnbaum | Zendy; Michael C. Mahaney | Zendy; David L. Rainwater | Zendy; Jeff T. Williams | Zendy; John L. VandeBerg | Zendy

Open Access

Identification of Promoter Variants in Baboon Endothelial Lipase That Regulate High-Density Lipoprotein Cholesterol Levels

Author(s) -

Laura A. Cox,

Shifra Birnbaum,

Michael C. Mahaney,

David L. Rainwater,

Jeff T. Williams,

John L. VandeBerg

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.704346

Subject(s) - genetics , biology , gene , single nucleotide polymorphism , locus (genetics) , genotype

High-density lipoprotein cholesterol (HDL) levels are a major risk factor for cardiovascular disease. Previously we identified a quantitative trait locus on baboon chromosome 18 that regulates HDL. From positional cloning studies and expression studies, we identified the endothelial lipase gene (LIPG) as the primary candidate gene for the quantitative trait locus. The mechanism by which LIPG variation influences HDL levels has not been determined.

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