Expression of Cholesteryl Ester Transfer Protein in Mice Promotes Macrophage Reverse Cholesterol Transport | Zendy

Hiroyuki Tanigawa | Zendy; Jeffrey T. Billheimer | Zendy; Junichiro Tohyama | Zendy; Yuzhen Zhang | Zendy; George H. Rothblat | Zendy; Daniel J. Rader | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Expression of Cholesteryl Ester Transfer Protein in Mice Promotes Macrophage Reverse Cholesterol Transport

Author(s) -

Hiroyuki Tanigawa,

Jeffrey T. Billheimer,

Junichiro Tohyama,

Yuzhen Zhang,

George H. Rothblat,

Daniel J. Rader

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.704254

Subject(s) - cholesterylester transfer protein , reverse cholesterol transport , scavenger receptor , endocrinology , medicine , cholesterol , apolipoprotein e , lipoprotein , apolipoprotein b , cholesteryl ester , high density lipoprotein , biology , disease

Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from high-density lipoproteins to apolipoprotein (apo) B-containing lipoproteins and in humans plays an important role in lipoprotein metabolism. However, the role that CETP plays in mediation of reverse cholesterol transport (RCT) remains unclear. We used a validated in vivo assay of macrophage RCT to test the effect of CETP expression in mice (which naturally lack CETP) on macrophage RCT, including in mice that lack the low-density lipoprotein receptor or the scavenger receptor class B, type I.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research