Altered Plasma Versus Vascular Biopterins in Human Atherosclerosis Reveal Relationships Between Endothelial Nitric Oxide Synthase Coupling, Endothelial Function, and Inflammation | Zendy

Charalambos Antoniades | Zendy; Cheerag Shirodaria | Zendy; Mark J. Crabtree | Zendy; Ruth Rinze | Zendy; Nicholas Alp | Zendy; Colin Cunnington | Zendy; Jonathan Diesch | Zendy; Dimitris Tousoulis | Zendy; Christodoulos Stefanadis | Zendy; Paul Leeson | Zendy; C Ratnatunga | Zendy; Ravi Pillai | Zendy; Keith M. Chan | Zendy

Open Access

Altered Plasma Versus Vascular Biopterins in Human Atherosclerosis Reveal Relationships Between Endothelial Nitric Oxide Synthase Coupling, Endothelial Function, and Inflammation

Author(s) -

Charalambos Antoniades,

Cheerag Shirodaria,

Mark J. Crabtree,

Ruth Rinze,

Nicholas Alp,

Colin Cunnington,

Jonathan Diesch,

Dimitris Tousoulis,

Christodoulos Stefanadis,

Paul Leeson,

C Ratnatunga,

Ravi Pillai,

Keith M. Chan

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.704155

Subject(s) - medicine , enos , tetrahydrobiopterin , endocrinology , nitric oxide , biopterin , superoxide , nitric oxide synthase type iii , endothelial dysfunction , endothelium , nitric oxide synthase , vascular disease , chemistry , biochemistry , enzyme

Tetrahydrobiopterin (BH4) is a key regulator of endothelial nitric oxide synthase (eNOS) activity and coupling. However, the extent to which vascular and/or systemic BH4 levels are altered in human atherosclerosis and the importance of BH4 bioavailability in determining endothelial function and oxidative stress remain unclear. We sought to define the relationships between plasma and vascular biopterin levels in patients with coronary artery disease and to determine how BH4 levels affect endothelial function, eNOS coupling, and vascular superoxide production.

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