Xenografted Adult Human Mesenchymal Stem Cells Provide a Platform for Sustained Biological Pacemaker Function in Canine Heart | Zendy

Alexei N. Plotnikov | Zendy; Iry. Shlapakova | Zendy; Matthias Szabolcs | Zendy; Peter Danilo | Zendy; Beverly H. Lorell | Zendy; Irina A. Potapova | Zendy; Zhongju Lu | Zendy; Amy B. Rosen | Zendy; Richard T. Mathias | Zendy; Peter R. Brink | Zendy; Richard B. Robinson | Zendy; Ira S. Cohen | Zendy; Michael R. Rosen | Zendy

Open Access

Xenografted Adult Human Mesenchymal Stem Cells Provide a Platform for Sustained Biological Pacemaker Function in Canine Heart

Author(s) -

Alexei N. Plotnikov,

Iry. Shlapakova,

Matthias Szabolcs,

Peter Danilo,

Beverly H. Lorell,

Irina A. Potapova,

Zhongju Lu,

Amy B. Rosen,

Richard T. Mathias,

Peter R. Brink,

Richard B. Robinson,

Ira S. Cohen,

Michael R. Rosen

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.703231

Subject(s) - mesenchymal stem cell , medicine , embryonic stem cell , stem cell , andrology , xenotransplantation , transfection , immunosuppression , transplantation , microbiology and biotechnology , immunology , endocrinology , cell culture , biology , pathology , biochemistry , genetics , gene

Biological pacemaking has been performed with viral vectors, human embryonic stem cells, and adult human mesenchymal stem cells (hMSCs) as delivery systems. Only with human embryonic stem cells are data available regarding stability for >2 to 3 weeks, and here, immunosuppression has been used to facilitate survival of xenografts. The purpose of the present study was to determine whether hMSCs provide stable impulse initiation over 6 weeks without the use of immunosuppression, the "dose" of hMSCs that ensures function over this period, and the catecholamine responsiveness of hMSC-packaged pacemakers.

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