Progesterone Regulates Cardiac Repolarization Through a Nongenomic Pathway | Zendy

Hiroaki Nakamura | Zendy; Junko Kurokawa | Zendy; Chang-Xi Bai | Zendy; Ken Asada | Zendy; Jun Xu | Zendy; Ronit V. Oren | Zendy; Zheng I. Zhu | Zendy; Colleen E. Clancy | Zendy; Mitsuaki Isobe | Zendy; Tetsushi Furukawa | Zendy

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Progesterone Regulates Cardiac Repolarization Through a Nongenomic Pathway

Author(s) -

Hiroaki Nakamura,

Junko Kurokawa,

Chang-Xi Bai,

Ken Asada,

Jun Xu,

Ronit V. Oren,

Zheng I. Zhu,

Colleen E. Clancy,

Mitsuaki Isobe,

Tetsushi Furukawa

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.702407

Subject(s) - medicine , repolarization , cardiology , endocrinology , pharmacology , electrophysiology

Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence suggests a role for progesterone; however, the effect of progesterone on cardiac repolarization remains undetermined.

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