Measles Virus Nucleoprotein Induces a Regulatory Immune Response and Reduces Atherosclerosis in Mice | Zendy

Hafid Aït-Oufella | Zendy; Branka Horvat | Zendy; Yann M. Kerdiles | Zendy; Olivier Herbin | Zendy; Pierre Gourdy | Zendy; J. Laschet | Zendy; Régine Merval | Zendy; Bruno Esposito | Zendy; Alain Tedgui | Zendy; Ziad Mallat | Zendy

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Measles Virus Nucleoprotein Induces a Regulatory Immune Response and Reduces Atherosclerosis in Mice

Author(s) -

Hafid Aït-Oufella,

Branka Horvat,

Yann M. Kerdiles,

Olivier Herbin,

Pierre Gourdy,

J. Laschet,

Régine Merval,

Bruno Esposito,

Alain Tedgui,

Ziad Mallat

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.699470

Subject(s) - measles virus , nucleoprotein , immunology , immune system , virus , medicine , virology , morbillivirus , measles , vaccination

Recent studies clearly suggest that regulatory T cells play a critical role in the control of the immunoinflammatory response in atherosclerosis and substantially limit lesion development. Measles virus infection or vaccination is associated with immune depression, in part through the induction of an antiinflammatory response by measles virus nucleoprotein. We hypothesized that the antiinflammatory properties of measles virus nucleoprotein may limit the development atherosclerosis.

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