CD137 Is Expressed in Human Atherosclerosis and Promotes Development of Plaque Inflammation in Hypercholesterolemic Mice | Zendy

Peder S. Olofsson | Zendy; Leif Å. Söderström | Zendy; Dick Wågsäter | Zendy; Yuri Sheikine | Zendy; Pauline Ocaya | Zendy; François Lang | Zendy; Catherine Rabu | Zendy; Lieping Chen | Zendy; Mats Rudling | Zendy; Pål Aukrust | Zendy; Ulf Hedin | Zendy; Gabrielle PaulssonBerne | Zendy; Allan Sirsjö | Zendy; Göran K. Hansson | Zendy

Open Access

CD137 Is Expressed in Human Atherosclerosis and Promotes Development of Plaque Inflammation in Hypercholesterolemic Mice

Author(s) -

Peder S. Olofsson,

Leif Å. Söderström,

Dick Wågsäter,

Yuri Sheikine,

Pauline Ocaya,

François Lang,

Catherine Rabu,

Lieping Chen,

Mats Rudling,

Pål Aukrust,

Ulf Hedin,

Gabrielle PaulssonBerne,

Allan Sirsjö,

Göran K. Hansson

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.699173

Subject(s) - proinflammatory cytokine , inflammation , tumor necrosis factor alpha , medicine , cd137 , immunology , cell adhesion molecule , cd8 , cancer research , immune system

Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L have been implicated in atherosclerosis.

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