Pioglitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-Density Lipoprotein Receptor–Null Mice | Zendy

Edward B. Thorp | Zendy; George Kuriakose | Zendy; Yatrik M. Shah | Zendy; Frank J. Gonzalez | Zendy; Ira Tabas | Zendy

Open Access

Pioglitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-Density Lipoprotein Receptor–Null Mice

Author(s) -

Edward B. Thorp,

George Kuriakose,

Yatrik M. Shah,

Frank J. Gonzalez,

Ira Tabas

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.698852

Subject(s) - pioglitazone , medicine , rosiglitazone , endocrinology , apoptosis , macrophage , tumor necrosis factor alpha , peroxisome proliferator activated receptor , cancer research , receptor , pharmacology , type 2 diabetes , diabetes mellitus , biology , in vitro , biochemistry

Thiazolidinediones (TZDs), which have actions that involve both peroxisome proliferator-activated receptor (PPAR)-gamma-dependent and -independent effects, improve insulin sensitivity in type II diabetes and inhibit early atherogenesis in mice. However, the effects of TZDs on advanced lesion progression are unknown.

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