Disruption of Type 5 Adenylyl Cyclase Enhances Desensitization of Cyclic Adenosine Monophosphate Signal and Increases Akt Signal With Chronic Catecholamine Stress | Zendy

Satoshi Okumura | Zendy; Dorothy E. Vatner | Zendy; Reiko Kurotani | Zendy; Yunzhe Bai | Zendy; Shumin Gao | Zendy; Zengrong Yuan | Zendy; Kousaku Iwatsubo | Zendy; Coskun Ulucan | Zendy; Jun-ichi Kawabe | Zendy; Kaushik Ghosh | Zendy; Stephen F. Vatner | Zendy; Yoshihiro Ishikawa | Zendy

Open Access

Disruption of Type 5 Adenylyl Cyclase Enhances Desensitization of Cyclic Adenosine Monophosphate Signal and Increases Akt Signal With Chronic Catecholamine Stress

Author(s) -

Satoshi Okumura,

Dorothy E. Vatner,

Reiko Kurotani,

Yunzhe Bai,

Shumin Gao,

Zengrong Yuan,

Kousaku Iwatsubo,

Coskun Ulucan,

Jun-ichi Kawabe,

Kaushik Ghosh,

Stephen F. Vatner,

Yoshihiro Ishikawa

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.698662

Subject(s) - adenylyl cyclase , medicine , desensitization (medicine) , cyclic adenosine monophosphate , endocrinology , catecholamine , adenosine , adcy6 , adcy3 , adcy9 , signal transduction , microbiology and biotechnology , receptor , stimulation , biology

Desensitization of the cyclic adenosine monophosphate signal protects cardiac myocytes against catecholamine stress, thus preventing the development of apoptosis. Molecular mechanisms of desensitization have been well studied at the level of adrenergic receptors but less so at the level of the effector enzyme, adenylyl cyclase (AC).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research