Signal Transducer and Activator of Transcription 1 Is Required for Optimal Foam Cell Formation and Atherosclerotic Lesion Development | Zendy

Sudesh Agrawal | Zendy; Maria Febbraio | Zendy; Eugene A. Podrez | Zendy; Martha K. Cathcart | Zendy; George R. Stark | Zendy; Guy Chisolm | Zendy

Open Access

Signal Transducer and Activator of Transcription 1 Is Required for Optimal Foam Cell Formation and Atherosclerotic Lesion Development

Author(s) -

Sudesh Agrawal,

Maria Febbraio,

Eugene A. Podrez,

Martha K. Cathcart,

George R. Stark,

Guy Chisolm

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.696922

Subject(s) - cd36 , foam cell , stat1 , scavenger receptor , stat protein , microbiology and biotechnology , medicine , cancer research , biology , receptor , stat3 , signal transduction , lipoprotein , cholesterol

Signal transducer and activator of transcription 1 (Stat1) potently regulates gene expression after stimulation by certain cytokines involved in tumorigenesis and host defenses. The present study investigated a novel role for Stat1 in foam cell formation and atherosclerosis.

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