Open AccessStromal Cell–Derived Factor-1α Is Cardioprotective After Myocardial Infarction
Author(s) -
Ankur Saxena,
Jason E. Fish,
Michael White,
Sangho Yu,
James W. Smyth,
Robin M. Shaw,
J. Michael DiMaio,
Deepak Srivastava
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.107.694992
Subject(s) - medicine , myocardial infarction , stromal cell , protein kinase b , infarction , myocyte , tissue factor , growth factor , vascular endothelial growth factor , cardiology , microbiology and biotechnology , signal transduction , receptor , biology , vegf receptors , coagulation
Heart disease is a leading cause of mortality throughout the world. Tissue damage from vascular occlusive events results in the replacement of contractile myocardium by nonfunctional scar tissue. The potential of new technologies to regenerate damaged myocardium is significant, although cell-based therapies must overcome several technical barriers. One possible cell-independent alternative is the direct administration of small proteins to damaged myocardium.
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