Targeting Platelets in Acute Experimental Stroke | Zendy

Christoph Kleinschnitz | Zendy; Miroslava Požgajová | Zendy; Mirko Pham | Zendy; Martin Bendszus | Zendy; Bernhard Nieswandt | Zendy; Guido Stoll | Zendy

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Targeting Platelets in Acute Experimental Stroke

Author(s) -

Christoph Kleinschnitz,

Miroslava Požgajová,

Mirko Pham,

Martin Bendszus,

Bernhard Nieswandt,

Guido Stoll

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.691279

Subject(s) - medicine , platelet , stroke (engine) , acute stroke , cardiology , intensive care medicine , tissue plasminogen activator , mechanical engineering , engineering

Ischemic stroke is a frequent and serious disease with limited treatment options. Platelets can adhere to hypoxic cerebral endothelial cells by binding of their glycoprotein (GP) Ib receptor to von Willebrand factor. Exposure of subendothelial matrix proteins further facilitates firm attachment of platelets to the vessel wall by binding of collagen to their GPVI receptor. In the present study, we addressed the pathogenic role of GPIb, GPVI, and the aggregation receptor GPIIb/IIIa in experimental stroke in mice.

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