CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Provides Myocardial Protection During Cardiac Ischemia/Reperfusion Injury | Zendy

D. Köhler | Zendy; Tobias Eckle | Zendy; Marion Faigle | Zendy; Almut Grenz | Zendy; Michel Mittelbronn | Zendy; Stefanie Laucher | Zendy; Melanie L. Hart | Zendy; Simon C. Robson | Zendy; Christa E. Müller | Zendy; Holger K. Eltzschig | Zendy

Open Access

CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Provides Myocardial Protection During Cardiac Ischemia/Reperfusion Injury

Author(s) -

D. Köhler,

Tobias Eckle,

Marion Faigle,

Almut Grenz,

Michel Mittelbronn,

Stefanie Laucher,

Melanie L. Hart,

Simon C. Robson,

Christa E. Müller,

Holger K. Eltzschig

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.690180

Subject(s) - medicine , reperfusion injury , cardiology , myocardial ischemia , ischemia , myocardial reperfusion injury , cardiac ischemia

Extracellular adenosine, generated from extracellular nucleotides via ectonucleotidases, binds to specific receptors and provides cardioprotection from ischemia and reperfusion. In the present study, we studied ecto-enzymatic ATP/ADP-phosphohydrolysis by select members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family during myocardial ischemia.

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