Mechanoelectrical Feedback as Novel Mechanism of Cardiac Electrical Remodeling | Zendy

Darwin Jeyaraj | Zendy; Lance D. Wilson | Zendy; Zhong Jia | Zendy; Chris A. Flask | Zendy; Jeffrey E. Saffitz | Zendy; Isabelle Deschênes | Zendy; Xin Yu | Zendy; David Rosenbaum | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanoelectrical Feedback as Novel Mechanism of Cardiac Electrical Remodeling

Author(s) -

Darwin Jeyaraj,

Lance D. Wilson,

Zhong Jia,

Chris A. Flask,

Jeffrey E. Saffitz,

Isabelle Deschênes,

Xin Yu,

David Rosenbaum

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.688317

Subject(s) - ventricle , repolarization , ventricular remodeling , electrophysiology , medicine , ion channel , cardiology , neuroscience , anatomy , heart failure , biology , receptor

Altered electrical activation of the heart by pacing or disease induces profound ventricular electrical remodeling (VER), manifested electrocardiographically as T-wave memory and ultimately as deleterious mechanical remodeling from heterogeneous strain. Although T-wave memory is associated with altered expression of sarcolemmal ion channels, the biophysical mechanisms responsible for triggering remodeling of cardiac ion channels are unknown.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research