MicroRNAs in the Human Heart | Zendy

Thomas Thum | Zendy; Paolo Galuppo | Zendy; Christian Wolf | Zendy; Jan Fiedler | Zendy; Susanne Kneitz | Zendy; Linda W. van Laake | Zendy; Pieter A. Doevendans | Zendy; Christine L. Mummery | Zendy; Jürgen Borlak | Zendy; Axel Haverich | Zendy; Carina Gross | Zendy; Stefan Engelhardt | Zendy; Georg Ertl | Zendy; Johann Bauersachs | Zendy

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MicroRNAs in the Human Heart

Author(s) -

Thomas Thum,

Paolo Galuppo,

Christian Wolf,

Jan Fiedler,

Susanne Kneitz,

Linda W. van Laake,

Pieter A. Doevendans,

Christine L. Mummery,

Jürgen Borlak,

Axel Haverich,

Carina Gross,

Stefan Engelhardt,

Georg Ertl,

Johann Bauersachs

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.687947

Subject(s) - microrna , gene expression , heart failure , transcriptome , regulation of gene expression , heart development , downregulation and upregulation , medicine , messenger rna , untranslated region , three prime untranslated region , biology , microbiology and biotechnology , bioinformatics , gene , genetics , embryonic stem cell

Chronic heart failure is characterized by left ventricular remodeling and reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here we provide evidence that cardiac microRNAs, recently discovered key regulators of gene expression, contribute to the transcriptional changes observed in heart failure.

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