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Aaron M. Allen | Zendy; Ina  Anreiter | Zendy; Megan C. Neville | Zendy; Marla B. Sokolowski | Zendy; Abdurrahman  Keskin | Zendy; Emel  Akdoğan | Zendy

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Issue Highlights

Author(s) -

Aaron M. Allen,

Ina Anreiter,

Megan C. Neville,

Marla B. Sokolowski,

Abdurrahman Keskin,

Emel Akdoğan

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.185633

Subject(s) - medicine

Alternative polyadenylation (APA) is observed in virtually all metazoans and results in mRNA isoforms with different 3’ends. It is routinely detected and can be altered in disease, but its biological role is still a mystery. Blazie et al. performed an in-depth analysis of the transcriptome and APAome of eight somatic tissues in worms and show mechanistic evidence that tissue-specific APA is used to evade miRNA regulation. This work also provides the first comprehensive tissue-specific worm transcriptome and APAome resource.

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