β 1 -Adrenergic Receptor Autoantibodies Mediate Dilated Cardiomyopathy by Agonistically Inducing Cardiomyocyte Apoptosis | Zendy

Dan Janewit | Zendy; Cengiz Z. Altuntas | Zendy; Justin M. Johnson | Zendy; Sandro L. Yong | Zendy; Peter J. Wickley | Zendy; Pamela Clark | Zendy; Qing Wang | Zendy; Zoran Popović | Zendy; Marc S. Penn | Zendy; Derek S. Damron | Zendy; Dianne M. Perez | Zendy; Vincent K. Tuohy | Zendy

Open Access

β ₁ -Adrenergic Receptor Autoantibodies Mediate Dilated Cardiomyopathy by Agonistically Inducing Cardiomyocyte Apoptosis

Author(s) -

Dan Janewit,

Cengiz Z. Altuntas,

Justin M. Johnson,

Sandro L. Yong,

Peter J. Wickley,

Pamela Clark,

Qing Wang,

Zoran Popović,

Marc S. Penn,

Derek S. Damron,

Dianne M. Perez,

Vincent K. Tuohy

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.683193

Subject(s) - autoantibody , medicine , apoptosis , receptor , endocrinology , signal transduction , antibody , immunology , microbiology and biotechnology , biology , biochemistry

Antibodies to the beta1-adrenergic receptor (beta1AR) are detected in a substantial number of patients with idiopathic dilated cardiomyopathy (DCM). The mechanism whereby these autoantibodies exert their pathogenic effect is unknown. Here, we define a causal mechanism whereby beta1AR-specific autoantibodies mediate noninflammatory cardiomyocyte cell death during murine DCM.

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