Intracoronary Administration of AdvFGF-5 (Fibroblast Growth Factor-5) Ameliorates Left Ventricular Dysfunction and Prevents Myocyte Loss in Swine With Developing Collaterals and Ischemic Cardiomyopathy | Zendy

Petra S Lynch | Zendy; Techung Lee | Zendy; James A. Fallavollita | Zendy; John M. Canty | Zendy; Gen Suzuki | Zendy

Open Access

Intracoronary Administration of AdvFGF-5 (Fibroblast Growth Factor-5) Ameliorates Left Ventricular Dysfunction and Prevents Myocyte Loss in Swine With Developing Collaterals and Ischemic Cardiomyopathy

Author(s) -

Petra S Lynch,

Techung Lee,

James A. Fallavollita,

John M. Canty,

Gen Suzuki

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.681866

Subject(s) - medicine , myocyte , cardiology , hibernating myocardium , perfusion , tunel assay , cardiac myocyte , cardiomyopathy , heart failure , endocrinology , myocardial infarction , revascularization , immunohistochemistry

Fibroblast growth factor (AdvFGF-5) improves regional function by stimulating myocyte hypertrophy without increasing myocardial perfusion in swine with hibernating myocardium. We performed the present study to determine whether AdvFGF-5 could prevent the progression of LV dysfunction in swine with ischemic cardiomyopathy.

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