Early Metoprolol Administration Before Coronary Reperfusion Results in Increased Myocardial Salvage | Zendy

Borja Ibáñez | Zendy; S Prat | Zendy; Walter S. Speidl | Zendy; Gemma Vilahur | Zendy; Antonio Piñero | Zendy; Giovanni Cimmino | Zendy; Mario J. García | Zendy; Valentı́n Fuster | Zendy; Javier Sanz | Zendy; Juan J. Badimón | Zendy

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Early Metoprolol Administration Before Coronary Reperfusion Results in Increased Myocardial Salvage

Author(s) -

Borja Ibáñez,

S Prat,

Walter S. Speidl,

Gemma Vilahur,

Antonio Piñero,

Giovanni Cimmino,

Mario J. García,

Valentı́n Fuster,

Javier Sanz,

Juan J. Badimón

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.679639

Subject(s) - medicine , metoprolol , cardiology

Beta-blockers improve clinical outcome when administered early after acute myocardial infarction. However, whether beta-blockers actually reduce the myocardial infarction size is still in dispute. Cardiac magnetic resonance imaging can accurately depict the left ventricular (LV) ischemic myocardium at risk (T2-weighted hyperintense region) early after myocardial infarction, as well as the extent of necrosis (delayed gadolinium enhancement). The aim of this study was to determine whether early administration of metoprolol could increase myocardial salvage, measured as the difference between the extent of myocardium at risk and myocardial necrosis.

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