CXCR6 Promotes Atherosclerosis by Supporting T-Cell Homing, Interferon-γ Production, and Macrophage Accumulation in the Aortic Wall | Zendy

Elena Galkina | Zendy; Brian L. Harry | Zendy; Andreas Ludwig | Zendy; Elisa A. Liehn | Zendy; John M. Sanders | Zendy; Anthony C. Bruce | Zendy; Christian Weber | Zendy; Klaus Ley | Zendy

Open Access

CXCR6 Promotes Atherosclerosis by Supporting T-Cell Homing, Interferon-γ Production, and Macrophage Accumulation in the Aortic Wall

Author(s) -

Elena Galkina,

Brian L. Harry,

Andreas Ludwig,

Elisa A. Liehn,

John M. Sanders,

Anthony C. Bruce,

Christian Weber,

Klaus Ley

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.678474

Subject(s) - homing (biology) , immune system , immunology , chemokine , medicine , apolipoprotein e , lymphocyte , t cell , interferon gamma , biology , ecology , disease

T lymphocytes are thought to be important in atherosclerosis, but very little is known about the mechanisms of lymphocyte recruitment into atherosclerosis-prone aortas. In this study we tested the hypothesis that CXCR6, a chemokine receptor that is expressed on a subset of CD4+ T helper 1 cells and natural killer T cells, is involved in lymphocyte homing into the aortic wall and modulates the development and progression of atherosclerosis.

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