Exercise Training Normalizes Sympathetic Outflow by Central Antioxidant Mechanisms in Rabbits With Pacing-Induced Chronic Heart Failure | Zendy

Lie Gao | Zendy; Wei Wang | Zendy; Dongmei Liu | Zendy; Irving H. Zucker | Zendy

Open Access

Exercise Training Normalizes Sympathetic Outflow by Central Antioxidant Mechanisms in Rabbits With Pacing-Induced Chronic Heart Failure

Author(s) -

Lie Gao,

Wei Wang,

Dongmei Liu,

Irving H. Zucker

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.677989

Subject(s) - medicine , baroreflex , heart rate , endocrinology , heart failure , superoxide dismutase , superoxide , oxidative stress , blood pressure , chemistry , biochemistry , enzyme

In a recent study, we demonstrated that an increase in oxidative stress in the rostral ventrolateral medulla plays a critical role in the sympathoexcitation observed in chronic heart failure (CHF). Growing evidence indicates that exercise training evokes an antioxidative effect in CHF. In the present study, we therefore hypothesized that long-term exercise exerts its beneficial effect on autonomic activity in CHF via central antioxidative mechanisms.

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