The pH Hypothesis of Postconditioning | Zendy

Michael V. Cohen | Zendy; XiMing Yang | Zendy; James M. Downey | Zendy

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The pH Hypothesis of Postconditioning

Author(s) -

Michael V. Cohen,

XiMing Yang,

James M. Downey

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.675710

Subject(s) - mitochondrial permeability transition pore , medicine , acidosis , cardioprotection , mptp , ischemia , pharmacology , reperfusion injury , anesthesia , myocardial infarction , cardiology , chemistry , biochemistry , apoptosis , dopaminergic , programmed cell death , dopamine

It is unclear how reperfusion of infarcting hearts with alternating cycles of coronary reperfusion/occlusion attenuates infarction, but prevention of mitochondrial permeability transition pore (MPTP) formation is crucial. Acidosis also suppresses MPTP formation. We tested whether postconditioning protects by maintaining acidosis during early reoxygenation.

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