Cell Therapy for Modification of the Myocardial Electrophysiological Substrate | Zendy

Lior Yankelson | Zendy; Yair Feld | Zendy; Tal Bressler-Stramer | Zendy; Ilanit Itzhaki | Zendy; Irit Huber | Zendy; Amira Gepstein | Zendy; Doron Aronson | Zendy; Shimon Marom | Zendy; Lior Gepstein | Zendy

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Cell Therapy for Modification of the Myocardial Electrophysiological Substrate

Author(s) -

Lior Yankelson,

Yair Feld,

Tal Bressler-Stramer,

Ilanit Itzhaki,

Irit Huber,

Amira Gepstein,

Doron Aronson,

Shimon Marom,

Lior Gepstein

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.671776

Subject(s) - in vivo , refractory period , ex vivo , transfection , electrophysiology , medicine , potassium channel , transplantation , myocyte , pharmacology , cell culture , cardiology , biology , genetics , microbiology and biotechnology

Traditional antiarrhythmic pharmacological therapies are limited by their global cardiac action, low efficacy, and significant proarrhythmic effects. We present a novel approach for the modification of the myocardial electrophysiological substrate using cell grafts genetically engineered to express specific ionic channels.

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