Statin Treatment in Children With Familial Hypercholesterolemia | Zendy

Jessica Rodenburg | Zendy; Maud N. Vissers | Zendy; Albert Wiegman | Zendy; A.S. Paul van Trotsenburg | Zendy; Anouk van der Graaf | Zendy; Eric de Groot | Zendy; Frits A. Wijburg | Zendy; John J.P. Kastelein | Zendy; Barbara A. Hutten | Zendy

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Statin Treatment in Children With Familial Hypercholesterolemia

Author(s) -

Jessica Rodenburg,

Maud N. Vissers,

Albert Wiegman,

A.S. Paul van Trotsenburg,

Anouk van der Graaf,

Eric de Groot,

Frits A. Wijburg,

John J.P. Kastelein,

Barbara A. Hutten

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.671016

Subject(s) - medicine , familial hypercholesterolemia , statin , ldl cholesterol , atherosclerotic cardiovascular disease , cardiology , pediatrics , cholesterol , disease

We previously demonstrated in a randomized placebo-controlled trial that 2-year pravastatin treatment induced a significant regression of carotid intima-media thickness (IMT) in 8- to 18-year-old children with familial hypercholesterolemia. Subsequently, we continued to follow up these children to explore the relation between the age of statin initiation and carotid IMT after follow-up on statin treatment. We also examined safety aspects of statin therapy during this long-term follow-up.

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