Recruitment of Compensatory Pathways to Sustain Oxidative Flux With Reduced Carnitine Palmitoyltransferase I Activity Characterizes Inefficiency in Energy Metabolism in Hypertrophied Hearts | Zendy

Н. И. Сорокина | Zendy; J. Michael O’Donnell | Zendy; Ronald McKinney | Zendy; Kayla M. Pound | Zendy; Gebre Woldegiorgis | Zendy; Kathryn F. LaNoue | Zendy; Kalpana Ballal | Zendy; Heinrich Taegtmeyer | Zendy; Peter M. Buttrick | Zendy; E. Douglas Lewandowski | Zendy

Open Access

Recruitment of Compensatory Pathways to Sustain Oxidative Flux With Reduced Carnitine Palmitoyltransferase I Activity Characterizes Inefficiency in Energy Metabolism in Hypertrophied Hearts

Author(s) -

Н. И. Сорокина,

J. Michael O’Donnell,

Ronald McKinney,

Kayla M. Pound,

Gebre Woldegiorgis,

Kathryn F. LaNoue,

Kalpana Ballal,

Heinrich Taegtmeyer,

Peter M. Buttrick,

E. Douglas Lewandowski

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.668665

Subject(s) - medicine , carnitine , energy metabolism , oxidative metabolism , oxidative phosphorylation , endocrinology , metabolism , carnitine o palmitoyltransferase , flux (metallurgy) , oxidative stress , beta oxidation , biochemistry , biology , materials science , metallurgy

Transport rates of long-chain free fatty acids into mitochondria via carnitine palmitoyltransferase I relative to overall oxidative rates in hypertrophied hearts remain poorly understood. Furthermore, the extent of glucose oxidation, despite increased glycolysis in hypertrophy, remains controversial. The present study explores potential compensatory mechanisms to sustain tricarboxylic acid cycle flux that resolve the apparent discrepancy of reduced fatty acid oxidation without increased glucose oxidation through pyruvate dehydrogenase complex in the energy-poor, hypertrophied heart.

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