Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease | Zendy

Dominick J. Angiolillo | Zendy; Steven B. Shoemaker | Zendy; Bhaloo Desai | Zendy; Hang Yuan | Zendy; Ronald K. Charlton | Zendy; Esther Bernardo | Zendy; Martin M. Zenni | Zendy; Luis A. Guzmán | Zendy; Theodore A. Bass | Zendy; Marco A. Costa | Zendy

Open Access

Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease

Author(s) -

Dominick J. Angiolillo,

Steven B. Shoemaker,

Bhaloo Desai,

Hang Yuan,

Ronald K. Charlton,

Esther Bernardo,

Martin M. Zenni,

Luis A. Guzmán,

Theodore A. Bass,

Marco A. Costa

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.667741

Subject(s) - clopidogrel , medicine , maintenance dose , platelet , diabetes mellitus , coronary artery disease , loading dose , clinical endpoint , dosing , antiplatelet drug , randomization , adenosine diphosphate , randomized controlled trial , ticlopidine , type 2 diabetes mellitus , pharmacology , aspirin , endocrinology , platelet aggregation

After treatment with clopidogrel, patients with type 2 diabetes mellitus (T2DM) have reduced platelet inhibition compared with patients who are not diabetic. Whether platelet inhibition can be enhanced by increasing clopidogrel maintenance dosage in T2DM patients is unknown. The aim of this pilot study was to assess the functional impact of a high maintenance dose in T2DM patients with suboptimal clopidogrel-induced antiplatelet effects.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research