Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide–Gated Pacemaker Channels by Clonidine | Zendy

Anne Knaus | Zendy; Xiangang Zong | Zendy; Nadine Beetz | Zendy; Roland Jahns | Zendy; Martin J. Lohse | Zendy; Martin Biel | Zendy; Lutz Hein | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide–Gated Pacemaker Channels by Clonidine

Author(s) -

Anne Knaus,

Xiangang Zong,

Nadine Beetz,

Roland Jahns,

Martin J. Lohse,

Martin Biel,

Lutz Hein

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.667675

Subject(s) - clonidine , medicine , bradycardia , sinoatrial node , endocrinology , diastole , pharmacology , heart rate , blood pressure

Inhibition of cardiac sympathetic tone represents an important strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation of presynaptic alpha2-adrenoceptors is the most widely accepted mechanism of action of the antisympathetic drug clonidine; however, other target proteins have been postulated to contribute to the in vivo actions of clonidine.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research