Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor-α/PGC-1α Gene Regulatory Pathway | Zendy

Jennifer G. Duncan | Zendy; Juliet L. Fong | Zendy; Denis M. Medeiros | Zendy; Brian N. Finck | Zendy; Daniel P. Kelly | Zendy

Open Access

Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor-α/PGC-1α Gene Regulatory Pathway

Author(s) -

Jennifer G. Duncan,

Juliet L. Fong,

Denis M. Medeiros,

Brian N. Finck,

Daniel P. Kelly

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.662296

Subject(s) - medicine , peroxisome , peroxisome proliferator activated receptor , insulin resistance , diabetes mellitus , endocrinology , insulin , mitochondrion , insulin receptor , obesity , function (biology) , receptor , microbiology and biotechnology , biology

Obesity and diabetes mellitus are complex metabolic problems of pandemic proportion, contributing to significant cardiovascular mortality. Recent studies have shown altered mitochondrial function in the hearts of diabetic animals. We hypothesized that regulatory events involved in the control of mitochondrial function are activated in the prediabetic, insulin-resistant stage.

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