Amplified Expression Profiling of Platelet Transcriptome Reveals Changes in Arginine Metabolic Pathways in Patients With Sickle Cell Disease | Zendy

Nalini Raghavachari | Zendy; Xiuli Xu | Zendy; Amy Harris | Zendy; José Villagra | Zendy; Carolea Logun | Zendy; Jennifer J. Barb | Zendy; Michael A. Solomon | Zendy; Anthony F. Suffredini | Zendy; Robert L. Danner | Zendy; Gregory J. Kato | Zendy; Peter J. Munson | Zendy; Sidney M. Morris | Zendy; Mark T. Gladwin | Zendy

Open Access

Amplified Expression Profiling of Platelet Transcriptome Reveals Changes in Arginine Metabolic Pathways in Patients With Sickle Cell Disease

Author(s) -

Nalini Raghavachari,

Xiuli Xu,

Amy Harris,

José Villagra,

Carolea Logun,

Jennifer J. Barb,

Michael A. Solomon,

Anthony F. Suffredini,

Robert L. Danner,

Gregory J. Kato,

Peter J. Munson,

Sidney M. Morris,

Mark T. Gladwin

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.658641

Subject(s) - transcriptome , platelet , fold change , medicine , platelet activation , microarray , gene expression profiling , gene expression , microarray analysis techniques , cell , arginine , gene , biology , immunology , biochemistry , amino acid

In sickle cell disease, ischemia-reperfusion injury and intravascular hemolysis produce endothelial dysfunction and vasculopathy characterized by reduced nitric oxide and arginine bioavailability. Recent functional studies of platelets in patients with sickle cell disease reveal a basally activated state, which suggests that pathological platelet activation may contribute to sickle cell disease vasculopathy.

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