Evidence for Microvascular Dysfunction in Hypertrophic Cardiomyopathy | Zendy

Steffen E. Petersen | Zendy; Michael JeroschHerold | Zendy; Lucy Hudsmith | Zendy; Matthew D. Robson | Zendy; Jane M Francis | Zendy; Helen Doll | Zendy; Joseph B. Selvanayagam | Zendy; Stefan Neubauer | Zendy; Hugh Watkins | Zendy

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Evidence for Microvascular Dysfunction in Hypertrophic Cardiomyopathy

Author(s) -

Steffen E. Petersen,

Michael JeroschHerold,

Lucy Hudsmith,

Matthew D. Robson,

Jane M Francis,

Helen Doll,

Joseph B. Selvanayagam,

Stefan Neubauer,

Hugh Watkins

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.657023

Subject(s) - medicine , hypertrophic cardiomyopathy , cardiology , muscle hypertrophy , perfusion , diastole , reactive hyperemia , fibrosis , left ventricular hypertrophy , sudden death , magnetic resonance imaging , cardiomyopathy , blood flow , heart failure , blood pressure , radiology

Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion reserve, and extent of fibrosis may offer new insights for future clinical risk stratification in HCM but require multiparametric imaging with high spatial and temporal resolution.

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