Mast Cell Stabilization Reduces Hemorrhage Formation and Mortality After Administration of Thrombolytics in Experimental Ischemic Stroke | Zendy

Daniel Strbian | Zendy; MarjaLiisa KarjalainenLindsberg | Zendy; Petri T. Kovanen | Zendy; Turgut Tatlisumak | Zendy; Perttu J. Lindsberg | Zendy

Open Access

Mast Cell Stabilization Reduces Hemorrhage Formation and Mortality After Administration of Thrombolytics in Experimental Ischemic Stroke

Author(s) -

Daniel Strbian,

MarjaLiisa KarjalainenLindsberg,

Petri T. Kovanen,

Turgut Tatlisumak,

Perttu J. Lindsberg

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.655423

Subject(s) - medicine , ischemic stroke , stroke (engine) , cardiology , anesthesia , ischemia , mechanical engineering , engineering

Thrombolysis with tissue plasminogen activator (tPA) improves stroke outcome, but hemorrhagic complications and reperfusion injury occasionally impede favorable prognosis after vessel recanalization. Perivascularly located cerebral mast cells (MCs) release on degranulation potent vasoactive, proteolytic, and fibrinolytic substances. We previously found MCs to increase ischemic and hemorrhagic brain edema and neutrophil accumulation. This study examined the role of MCs in tPA-mediated hemorrhage formation (HF) and reperfusion injury.

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