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Infarct Tissue Heterogeneity by Magnetic Resonance Imaging Identifies Enhanced Cardiac Arrhythmia Susceptibility in Patients With Left Ventricular Dysfunction
Author(s) -
André Schmidt,
Clerio F. Azevedo,
Alan Cheng,
Sandeep Gupta,
David A. Bluemke,
Thomas Foo,
Gary Gerstenblith,
Robert G. Weiss,
Eduardo Marbán,
Gordon F. Tomaselli,
João A.C. Lima,
Kathérine C. Wu
Publication year - 2007
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.106.653568
Subject(s) - medicine , cardiology , magnetic resonance imaging , cardiac magnetic resonance , cardiac magnetic resonance imaging , cardiac dysfunction , cardiac arrhythmia , radiology , atrial fibrillation , heart failure
The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has been related to all-cause mortality in patients with coronary artery disease. This relationship may result from arrhythmogenesis in the infarct border. However, the relationship between tissue heterogeneity in the infarct periphery and arrhythmic substrate has not been investigated. In the present study, we quantify myocardial infarct heterogeneity by contrast-enhanced MRI and relate it to an electrophysiological marker of arrhythmic substrate in patients with left ventricular (LV) systolic dysfunction undergoing prophylactic implantable cardioverter defibrillator placement.

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