High-Dose Allopurinol Improves Endothelial Function by Profoundly Reducing Vascular Oxidative Stress and Not by Lowering Uric Acid | Zendy

George Casella | Zendy; Elaine Carr | Zendy; Justine Davies | Zendy; J. J. F. Belch | Zendy; Allan D. Struthers | Zendy

Open Access

High-Dose Allopurinol Improves Endothelial Function by Profoundly Reducing Vascular Oxidative Stress and Not by Lowering Uric Acid

Author(s) -

George Casella,

Elaine Carr,

Justine Davies,

J. J. F. Belch,

Allan D. Struthers

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.651117

Subject(s) - allopurinol , medicine , uric acid , oxidative stress , sodium nitroprusside , xanthine oxidase inhibitor , gout , placebo , endothelial dysfunction , endocrinology , papaverine , pharmacology , xanthine oxidase , nitric oxide , biochemistry , chemistry , pathology , alternative medicine , enzyme

Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish its mechanism of action and to construct a dose-response curve for the effect of allopurinol.

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