Heredity of Endothelin Secretion | Zendy

Elizabeth O. Lillie | Zendy; Manjula Mahata | Zendy; Srikrishna Khandrika | Zendy; Fangwen Rao | Zendy; Richard A. Bundey | Zendy; Gen Wen | Zendy; Yuqing Chen | Zendy; Laurent Taupenot | Zendy; Doug W. Smith | Zendy; Sushil K. Mahata | Zendy; Michael G. Ziegler | Zendy; Myles Cockburn | Zendy; Nicholas J. Schork | Zendy; Daniel T. O’Connor | Zendy

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Heredity of Endothelin Secretion

Author(s) -

Elizabeth O. Lillie,

Manjula Mahata,

Srikrishna Khandrika,

Fangwen Rao,

Richard A. Bundey,

Gen Wen,

Yuqing Chen,

Laurent Taupenot,

Doug W. Smith,

Sushil K. Mahata,

Michael G. Ziegler,

Myles Cockburn,

Nicholas J. Schork,

Daniel T. O’Connor

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.648345

Subject(s) - chromogranin a , umbilical vein , haplotype , endocrinology , medicine , allele , single nucleotide polymorphism , phenotype , gene , genetics , microbiology and biotechnology , biology , genotype , in vitro , immunohistochemistry

Endothelial dysfunction predisposes to vascular injury in association with hypertension. Endothelin (ET-1) is a potent vasoactive peptide that is synthesized and released by the vascular endothelium and is a marker of endothelial function. Chromogranin A (CHGA) regulates the storage and release of catecholamines and may have direct actions on the microvasculature. CHGA, a candidate gene for intermediate phenotypes that contribute to hypertension, shows a pattern of single nucleotide polymorphism variations that alter the expression and function of this gene both in vivo and in vitro.

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