Enhanced External Counterpulsation Inhibits Intimal Hyperplasia by Modifying Shear Stress–Responsive Gene Expression in Hypercholesterolemic Pigs | Zendy

Yan Zhang | Zendy; HE Xiao-hong | Zendy; Xiaolin Chen | Zendy; Hong Ma | Zendy; Donghong Liu | Zendy; Jinyun Luo | Zendy; Zhi-Min Du | Zendy; Yafei Jin | Zendy; Yan Xiong | Zendy; Jiangui He | Zendy; Dian-qiu Fang | Zendy; Kuijian Wang | Zendy; William E. Lawson | Zendy; John C.K. Hui | Zendy; Zhensheng Zheng | Zendy; Guifu Wu | Zendy

Open Access

Enhanced External Counterpulsation Inhibits Intimal Hyperplasia by Modifying Shear Stress–Responsive Gene Expression in Hypercholesterolemic Pigs

Author(s) -

Yan Zhang,

HE Xiao-hong,

Xiaolin Chen,

Hong Ma,

Donghong Liu,

Jinyun Luo,

Zhi-Min Du,

Yafei Jin,

Yan Xiong,

Jiangui He,

Dian-qiu Fang,

Kuijian Wang,

William E. Lawson,

John C.K. Hui,

Zhensheng Zheng,

Guifu Wu

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.647248

Subject(s) - medicine , intimal hyperplasia , shear stress , cardiology , gene expression , hyperplasia , gene , endocrinology , smooth muscle , genetics , materials science , biology , composite material

Enhanced external counterpulsation (EECP) is a circulation assist device that may improve endothelial dysfunction by increasing shear stress. Chronic exposure of vascular endothelial cells and vascular smooth muscle cells to relatively high physiological shear stress has antiproliferative and vasoprotective effects. The present study hypothesizes that EECP inhibits intimal hyperplasia and atherogenesis by modifying shear stress-responsive gene expression.

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