Cyclooxygenase-2 Inhibition Increases Mortality, Enhances Left Ventricular Remodeling, and Impairs Systolic Function After Myocardial Infarction in the Pig | Zendy

Leo Timmers | Zendy; Joost P. G. Sluijter | Zendy; Cees W.J. Verlaan | Zendy; Paul Steendijk | Zendy; Maarten J. Cramer | Zendy; Maringa Emons | Zendy; Chaylendra Strijder | Zendy; Paul F. Gründeman | Zendy; Siu Kwan Sze | Zendy; Lin Hua | Zendy; Jan J. Piek | Zendy; Cornelius Borst | Zendy; Gerard Pasterkamp | Zendy; Dominique P.V. de Kleijn | Zendy

Open Access

Cyclooxygenase-2 Inhibition Increases Mortality, Enhances Left Ventricular Remodeling, and Impairs Systolic Function After Myocardial Infarction in the Pig

Author(s) -

Leo Timmers,

Joost P. G. Sluijter,

Cees W.J. Verlaan,

Paul Steendijk,

Maarten J. Cramer,

Maringa Emons,

Chaylendra Strijder,

Paul F. Gründeman,

Siu Kwan Sze,

Lin Hua,

Jan J. Piek,

Cornelius Borst,

Gerard Pasterkamp,

Dominique P.V. de Kleijn

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.647230

Subject(s) - medicine , cardiology , ventricular remodeling , myocardial infarction , ventricular function , cyclooxygenase , enzyme , biochemistry , chemistry

Cyclooxygenase (COX)-2 expression in the heart increases after myocardial infarction (MI). In murine models of MI, COX-2 inhibition preserves left ventricular dimensions and function. We studied the effect of selective COX-2 inhibition on left ventricular remodeling and function after MI in a pig model.

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