Critical Role of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 in the Pathogenesis of Ischemic Cardiomyopathy | Zendy

Nikolaos G. Frangogiannis | Zendy; Oliver Dewald | Zendy; Ying Xia | Zendy; Guofeng Ren | Zendy; Sandra B. Haudek | Zendy; Thorsten M. Leucker | Zendy; Daniela Kraemer | Zendy; George E. Taffet | Zendy; Barrett J. Rollins | Zendy; Mark L. Entman | Zendy

Open Access

Critical Role of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 in the Pathogenesis of Ischemic Cardiomyopathy

Author(s) -

Nikolaos G. Frangogiannis,

Oliver Dewald,

Ying Xia,

Guofeng Ren,

Sandra B. Haudek,

Thorsten M. Leucker,

Daniela Kraemer,

George E. Taffet,

Barrett J. Rollins,

Mark L. Entman

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.646091

Subject(s) - medicine , pathogenesis , ischemic cardiomyopathy , monocyte , chemokine , ccr2 , chemotaxis , chemokine receptor , cardiomyopathy , immunology , cardiology , inflammation , receptor , heart failure , ejection fraction

Cardiac interstitial fibrosis plays an important role in the pathogenesis of ischemic cardiomyopathy, contributing to systolic and diastolic dysfunction. We have recently developed a mouse model of fibrotic noninfarctive cardiomyopathy due to brief repetitive myocardial ischemia and reperfusion. In this model, fibrotic changes are preceded by marked and selective induction of the CC chemokine monocyte chemoattractant protein-1 (MCP-1). We hypothesized that MCP-1 may mediate fibrotic remodeling through recruitment of mononuclear cells and direct effects on fibroblasts.

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