Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy | Zendy

Michelle S.C. Khoo | Zendy; Jingdong Li | Zendy; Madhu V. Singh | Zendy; Yingbo Yang | Zendy; Prince J. Kannankeril | Zendy; Yuejin Wu | Zendy; Chad E. Grueter | Zendy; Xiaoqun Guan | Zendy; Carmine V. Oddis | Zendy; Rong Zhang | Zendy; Lisa A. Mendes | Zendy; Gemin Ni | Zendy; Ernest C. Madu | Zendy; Jinying Yang | Zendy; Martha A. Bass | Zendy; Rey J. Gomez | Zendy; Brian E. Wadzinski | Zendy; Eric N. Olson | Zendy; Roger Colbran | Zendy; Mark E. Anderson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy

Author(s) -

Michelle S.C. Khoo,

Jingdong Li,

Madhu V. Singh,

Yingbo Yang,

Prince J. Kannankeril,

Yuejin Wu,

Chad E. Grueter,

Xiaoqun Guan,

Carmine V. Oddis,

Rong Zhang,

Lisa A. Mendes,

Gemin Ni,

Ernest C. Madu,

Jinying Yang,

Martha A. Bass,

Rey J. Gomez,

Brian E. Wadzinski,

Eric N. Olson,

Roger Colbran,

Mark E. Anderson

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.644583

Subject(s) - calcineurin , genetically modified mouse , transgene , medicine , cardiomyopathy , endocrinology , calmodulin , nfat , cardiac function curve , sudden death , phosphatase , heart failure , microbiology and biotechnology , biology , phosphorylation , transplantation , calcium , biochemistry , gene

Activation of cellular Ca2+ signaling molecules appears to be a fundamental step in the progression of cardiomyopathy and arrhythmias. Myocardial overexpression of the constitutively active Ca2+-dependent phosphatase calcineurin (CAN) causes severe cardiomyopathy marked by left ventricular (LV) dysfunction, arrhythmias, and increased mortality rate, but CAN antagonist drugs primarily reduce hypertrophy without improving LV function or risk of death.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research