HFE Genotype, Particulate Air Pollution, and Heart Rate Variability | Zendy

Sung Kyun Park | Zendy; Marie S. O’Neill | Zendy; Robert O. Wright | Zendy; Howard Hu | Zendy; Pantel Vokonas | Zendy; David Sparrow | Zendy; Helen Suh | Zendy; Joel Schwartz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

HFE Genotype, Particulate Air Pollution, and Heart Rate Variability

Author(s) -

Sung Kyun Park,

Marie S. O’Neill,

Robert O. Wright,

Howard Hu,

Pantel Vokonas,

David Sparrow,

Helen Suh,

Joel Schwartz

Publication year - 2006

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.106.643197

Subject(s) - particulates , heart rate variability , medicine , confounding , aerodynamic diameter , heart rate , cardiology , environmental chemistry , physiology , endocrinology , chemistry , blood pressure , biology , ecology

Particulate air pollution has been associated with cardiovascular mortality and morbidity. Transition metals such as iron bound to the particles may be responsible for those associations. The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research