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Dimethyl Sulfoxide Inhibits Tissue Factor Expression, Thrombus Formation, and Vascular Smooth Muscle Cell Activation
Author(s) -
Giovanni G. Camici,
Jan Steffel,
Alexander Akhmedov,
Nicola Schäfer,
Jeannette Baldinger,
Urs Schulz,
Kushiar Shojaati,
Christian M. Matter,
Zhihong Yang,
Thomas F. Lüscher,
Felix C. Tanner
Publication year - 2006
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.106.638460
Subject(s) - tissue factor , vascular smooth muscle , dimethyl sulfoxide , medicine , microbiology and biotechnology , chemistry , biology , organic chemistry , smooth muscle , coagulation
Subacute stent thrombosis is a major clinical concern, and the search for new molecules to cover stents remains important. Dimethyl sulfoxide (DMSO) is used for preservation of hematopoietic progenitor cells and is infused into patients undergoing bone marrow transplantation. Despite its intravenous application, the impact of DMSO on vascular cells has not been assessed.

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